Combined Effects of Dietary Phytoestrogen and Synthetic Endocrine-Active Compound on Reproductive Development in Sprague-Dawley Rats: Genistein and Methoxychlor
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چکیده
منابع مشابه
Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor.
Humans and wildlife are frequently exposed to mixtures of endocrine active-compounds (EAC). The objective of the present study was to investigate the potential of the phytoestrogen genistein to influence the reproductive developmental toxicity of the endocrine-active pesticide methoxychlor. Three levels of genistein (0, 300, or 800 ppm) and two levels of methoxychlor (0 or 800 ppm) were used in...
متن کاملEffects of the phytoestrogen genistein on the development of the reproductive system of Sprague Dawley rats
OBJECTIVES Genistein is known to influence reproductive system development through its binding affinity for estrogen receptors. The present study aimed to further explore the effect of Genistein on the development of the reproductive system of experimental rats. METHODS Eighteen post-weaning female Sprague Dawley rats were divided into the following groups: (i) a control group that received v...
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Genistein (Gen), is commonly consumed phytoestrogen among Asian and known to exert weak estrogenic effects. To account for potential reproductive effects in male rats, Control, Gen1, Gen10, Gen100 mg/kg body weight and Estradiol were administered to gestational day 10 (GD10) female Sprague Dawley for 5 weeks. At postnatal day, P50, the rats were sacrificed. Blood was taken and reproductive tiss...
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15 صفحه اولReproductive and Developmental Toxicity of Amitraz in Sprague-Dawley Rats
The present study was conducted to obtain information on the effects of amitraz on reproductive and developmental parameters in rats. The test chemical was administered via the drinking water containing 0, 40, 120, and 360 ppm to male rats from 2 weeks before mating to the end of 14-day mating period and to females from 2 weeks before mating, throughout mating, gestation and up to lactational d...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2002
ISSN: 1096-0929
DOI: 10.1093/toxsci/66.1.91